POTENTIAL RISKS IN MODERN ANTIBIOTIC THERAPY

Knowledge of the safety profile antibacterial drugs is important for rational pharmacotherapy with antibiotics. The purpose this information to help doctor, pharmacist and patient (quickly) "navigate" in antibiotics implement one basic principles "Do no harm!". aim study. Analysis possible potential risks modern antibiotic therapy. Materials methods. data from scientific literature on side effects Results. Most have a wide spectrum antimicrobial action, much less them narrow activity, but all (SE). In particular, neurotoxicity penicillins fluoroquinolones consequence their antagonism GABA. latter mechanism also responsible carbapenens, monobactams cephalosporins. Cardiotoxicity hematotoxicity benzylpenicillins are result inhibition tissue respiration process converting fibrinogen fibrin, which causes bleeding. carbopenicillins, cephalosporins associated conversion vicasol (vit. K) into its active form, as well obstruction synthesis due suppression normal intestinal microflora (the main producer endogenous vit. K). nephrotoxicity aminoglycosides vancomycin accumulation these cells proximal renal tubules impaired enzyme activity (Na+-, K+-, ATP; respiratory, etc.), leads interstitial nephritis. Ototoxicity observed when they used over age 60 – factor that predisposes ototoxicity. Conclusions. order conduct effective therapy, it very take account characteristic certain groups each representatively individual.